Mortality and Second Cancer Incidence Following Remedy for Testicular Most cancers: Psychosocial Health and Way of life Are Modifiable Prognostic Factors

Abstract

To appraise irrespective of whether picked modifiable patient-described adverse health results (AHOs) in testicular most cancers survivors (TCSs) stand for prognostic things of over-all mortality, cancer mortality, and very first-time non–germ mobile next most cancers (SecCa) incidence.

In 775 extensive-time period TCSs (analysis: 1980-1994) who previously participated in a quality-of-daily life study, 20-12 months mortality and SecCa incidence have been in contrast concerning the surgical treatment team (n = 272) and TCSs following platinum-based mostly chemotherapy (PBCT n = 503). A PBCT conventional group (overall cisplatin: ≤ 630 mg: n = 124) was divided from a PBCT higher subgroup (whole cisplatin: 630 mg n = 379). Univariate and multivariate analyses (Kaplan-Meier Cox proportional hazard analyses) provided age, treatment method, and prior main actual physical comorbidity as nonmodifiable variables, while small socioeconomic standing, harmful way of living, probable depression condition, and neurotoxicity were modifiable AHOs.

For all TCSs, the cumulative overall 20-yr mortality was 14% (95% CI, 11.8 to 16.8). Soaring age, PBCT large, and comorbidity considerably enhanced the chance of in general mortality price. Compared with a lower-hazard group (no AHO n = 446) and with exception of neurotoxicity, this chance was further noticeably increased by 80% in TCSs of a medium-possibility group (a person or two AHOs n = 278). In men of a significant-hazard team (three AHOs n = 47), the chance of over-all mortality and of most cancers mortality was 8-fold and five-fold elevated, respectively. Hazard grouping did not impact on SecCa incidence.

Self-described unfavorable modifiable AHO relating to life style and psychosocial wellness are in TCSs independently and drastically involved with greater over-all mortality and cancer mortality. Wellbeing professionals and the TCSs themselves, notably these soon after PBCT large, ought to continuously be aware of these hazard things attempting maximal reduction of these AHOs and

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Healthy lifestyle, medication adherence tied to lower mortality in hypertension

February 01, 2022

3 min read


Disclosures:
The authors report no relevant financial disclosures.


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The combination of healthy lifestyle and adherence to antihypertensive medications was associated with decreased risk for mortality in patients with hypertension, according to data in JAMA Network Open.

“No study has examined the joint association of antihypertensive medication use and healthy lifestyle with mortality among individuals with hypertension, to our knowledge. In addition, whether improvement in lifestyle may yield health benefits for individuals with hypertension is unclear,” Qi Lu, MBBS, of the department of nutrition and food hygiene at the Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (Incubating) at Tongji Medical College, Huazhong University of Science and Technology in Wuhan, China, and colleagues wrote. “To fill these knowledge gaps, we aimed to prospectively examine the association of antihypertensive medication use and healthy lifestyle, as well as changes in lifestyle, with risk of all-cause and cause-specific mortality among middle-aged and elderly adults with hypertension in China.”


Graphical depiction of data presented in article

Data were derived from Lu Q, et al. JAMA Netw Open. 2022;doi:10.1001/jamanetworkopen.2021.46118.

Utilizing data from the Dongfeng-Tongji prospective cohort of employees at the Dongfeng Motor Corporation in China, researchers evaluated lifestyle factors, including BMI, smoking status, diet, physical activity and sleep duration. Lifestyle factors were scored on a

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